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KMID : 0377519830080040373
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Chung-Ang Journal of Medicine
1983 Volume.8 No. 4 p.373 ~ p.380
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Immunohistochemical Observation of Carcinoembryonic Antigen in the Entoderm-derived fetal organs
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Chun Haeng-Jo
Yoo Jae-Hyung
Song Kye-Yong
Chi Je-Geun
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Abstract
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Since Gold and Freedman discovered the carcinoembryonic antigen (CEA) in 1965, CEA had been used as a tumor marker of gastrointestinal carcinoma for the evaluation of surgical treatment and prognosis. The CEA is also known to present in normal developing tissue. However, the knowledge on CEA in human fetal tissue is still incomplete. In this study CEA in the entoderm-derived fetal organs such as pancreas(22 cases), trachea(16 cases) and liver (10cases) was examined in the fetuses ranging in age from the 16th to the 39th week gestation by using immunoperoxidase (peroxidase-antiperoxidase) method. The results obtained were as follows: 1. CEA of the pancreas in the fetus’ CEA of the luminal border and cytoplasm of the acinar epithelium and Langerhans’ islets in pancreas was demonstrated by the 16th week of gestation. CEA positive reaction was gradually increased to the 19th and 20th week of gestation and was continued to present until the 33th week of gestation. 2. CEA of the trachea in the fetus CEA of the surface epithelium and glands of the trachea was demonstrated by the 17th week of gestation. Its activity was increased to reach the peak by the 20th week of gestation and gradually decreased by the 38th week of gestation. 3. CEA of the liver in the fetus CEA of the fetal liver was only demonstrated in the bile canaliculi without its positivity of the hepatocytes and intrahepatic bile ducts from the 19th to 30th week of gestation. Therefore it is assumed that the liver is not the site of CEA synthesis but is probably responsible for the degradation and excretion of CEA.
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KEYWORD
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